Group of regulatory transcriptomics and epigenomics

Yulia A. Medvedeva
Head of the Group
Ph.D. (Biology)
INB, room 301
Телефон
E-Mail ju.medvedeva@gmail.com

The group is currently working on several projects on epigenetic regulation:

1) Search for the agents targeting epigenetic modifiers to specific genomic locations (with the support from Russian Science Foundation for 2015-2017). Anatoliy Zubritskiy is mostly focused on this project searching for possible genetic determinants of epigenetic modifications using targeted genome editing.

2) Study of the role of lncRNA in transcription and post-transcription regulation. In particular, the group is interested in RNA-RNA and RNA-chromatin interaction. Ivan Antonov research interests include bioinformatics prediction of RNA-RNA interactions, post-transcriptional and epigenetic gene regulation. He is currently studying functions and molecular mechanisms of long non-coding RNAs in mammalian cells.

3) Detection of single CpG methylation markers highly specific for gene expresion. Anna Lioznova is now working on this topic.

Additionally, in late 2017 we started a collaborative project (with the support from RFBS for 2017-2019) on transcription and epigenetic regulation of macrophages during development of Mycobacterium tuberculosis infection. Also, Ivan Antonov works on programmed ribosomal frameshifting.

 

Selected publications:

  1. Antonov I, Marakhonov A, Zamkova M, Medvedeva Y. ASSA: Fast identification of statistically significant interactions between long RNAs. J Bioinform Comput. Biol. 2018 Jan 29
  2. Kulakovskiy IV, Vorontsov IE, Yevshin IS, Sharipov RN, Fedorova AD, Rumynskiy E, Medvedeva YA, Magana-Mora A, Bajic VB, Papatsenko DA, Kolpakov FA, Makeev VJ. HOCOMOCO: towards a complete collection of transcription factor binding models for human and mouse via large-scale ChIP-Seq analysis. Nucleic Acids Res. 2017 Nov 11. doi: 10.1093/nar/gkx1106.
  3. Artemov AV, Mugue NS, Rastorguev SM, Zhenilo S, Mazur AM, Tsygankova SV, Boulygina ES, Kaplun D, Nedoluzhko AV, Medvedeva YA, Prokhortchouk EB. Genome-Wide DNA Methylation Profiling Reveals Epigenetic Adaptation of Stickleback to Marine and Freshwater Conditions. Mol Biol Evol. 2017 Sep 1;34(9):2203-2213. doi: 10.1093/molbev/msx156.
  4. de Rie D, Abugessaisa I, Alam T, Arner E, Arner P, Ashoor H, Åström G, Babina M, Bertin N, Burroughs AM, Carlisle AJ, Daub CO, Detmar M, Deviatiiarov R, Fort A, Gebhard C, Goldowitz D, Guhl S, Ha TJ, Harshbarger J, Hasegawa A, Hashimoto K, Herlyn M, Heutink P, Hitchens KJ, Hon CC, Huang E, Ishizu Y, Kai C, Kasukawa T, Klinken P, Lassmann T, Lecellier CH, Lee W, Lizio M, Makeev V, Mathelier A, Medvedeva YA, Mejhert N, Mungall CJ, Noma S, Ohshima M, Okada-Hatakeyama M, Persson H, Rizzu P, Roudnicky F, Sætrom P, Sato H, Severin J, Shin JW, Swoboda RK, Tarui H, Toyoda H, Vitting-Seerup K, Winteringham L, Yamaguchi Y, Yasuzawa K, Yoneda M, Yumoto N, Zabierowski S, Zhang PG, Wells CA, Summers KM, Kawaji H, Sandelin A, Rehli M; FANTOM Consortium, Hayashizaki Y, Carninci P, Forrest ARR, de Hoon MJL. An integrated expression atlas of miRNAs and their promoters in human and mouse. Nat Biotechnol. 2017 Sep;35(9):872-878. doi: 10.1038/nbt.3947.
  5. Hon CC, Ramilowski JA, Harshbarger J, Bertin N, Rackham OJ, Gough J, Denisenko E, Schmeier S, Poulsen TM, Severin J, Lizio M, Kawaji H, Kasukawa T, Itoh M, Burroughs AM, Noma S, Djebali S, Alam T, Medvedeva YA, Testa AC, Lipovich L, Yip CW, Abugessaisa I, Mendez M, Hasegawa A, Tang D, Lassmann T, Heutink P, Babina M, Wells CA, Kojima S, Nakamura Y, Suzuki H, Daub CO, de Hoon MJ, Arner E, Hayashizaki Y, Carninci P, Forrest AR. An atlas of human long non-coding RNAs with accurate 5′ ends. Nature. 2017 Mar 9;543(7644):199-204.
  6. Lizio M, Harshbarger J, Abugessaisa I, Noguchi S, Kondo A, Severin J1, Mungall C, Arenillas D, Mathelier A, Medvedeva YA, Lennartsson A, Drabløs F, Ramilowski JA, Rackham O, Gough J, Andersson R, Sandelin A, Ienasescu H, Ono H, Bono H, Hayashizaki Y, Carninci P, Forrest AR, Kasukawa T, Kawaji H (2016)  Update of the FANTOM web resource: high resolution transcriptome of diverse cell types in mammals. NAR, Nucleic Acids Res.2016 Oct 27. pii: gkw995
  7. Panchin AY., Makeev VJ., Medvedeva YA. (2016) Preservation of methylated CpG dinucleotides in human CpG islands, Biology Direct, 11:11
  8. Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. (2016) HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res., D1:D116-D125.
  9. Medvedeva YA, Lennartsson A, Ehsani R, Kulakovskiy IV, Vorontsov IE, Panahandeh P, Khimulya G, Kasukawa T; FANTOM  Consortium, Drabløs F. (2015) EpiFactors: a comprehensive database of human epigenetic factors and complexes. Database (Oxford). 2015 Jul 7;2015:bav067. doi: 10.1093/database/bav067.
  10. A.Khamis, A.Hamilton, Y.Medvedeva, T.Alam, I.Alam, M.Essack, B.Umylny, B.Jankovic, N.Naeger, M.Suzuki, M.Harbers, G.Robinson, and V.Bajic (2015) Insights into the Transcriptional Architecture of Behavioral Plasticity in the Honey Bee Apis mellifera. Scientific Reports, Jun 15;5:11136
  11. Alam T, Medvedeva YA, Jia H, Brown JB, Lipovich L, Bajic VB (2014). Promoter analysis reveals globally differential regulation of human long non-coding RNA and protein-coding genes. PLoS One. Oct 2;9(10):e109443.
  12. A.R.R. Forrest, H. Kawaji, M. Rehli, J.K. Baillie, M.J.L. de Hoon, V. Haberle, T. Lassmann, I.V. Kulakovskiy, M. Lizio, M. Itoh, R. Andersson, C.J. Mungall, T.F. Meehan, S. Schmeier, N. Bertin, M. Jørgensen, E. Dimont, E. Arner, C. Schmidl, U. Schaefer, Y. A. Medvedeva, C. Plessy, M. Vitezic, J. Severin, C.A. Semple, Y. Ishizu, M. Francescatto, et al. (2014) A promoter level mammalian expression atlas. Nature. 507(7493):462-70. 2.
  13. Y.A. Medvedeva, A. Khamis, I.V. Kulakovskiy, W. Ba-Alawi, Md.S.I. Bhuyan, H. Kawaji, T. Lassmann, M. Harbers, A.R.R. Forrest and V.B. Bajic (2014). Effects of cytosine methylation on transcription factor binding sites. BMC genomics. 26;15(1):119.
  14. Kulakovskiy IV, Medvedeva YA, Schaefer U, Kasianov AS, Vorontsov IE, Bajic VB, Makeev VJ. (2013) HOCOMOCO: a comprehensive collection of human transcription factor binding sites models. Nucleic Acids Res. Jan;41(Database issue):D195-202.
  15. Antonov I, Baranov PV, Borodovsky M (2013) GeneTack database: genes with frameshifts in prokaryotic genomes and eukaryotic mRNA sequences. Nucleic Acids Res. 2013 Jan;41:D152-6
  16. Antonov I, Coakley A, Atkins JF, Baranov PV, Borodovsky M. Identification of the nature of reading frame transitions observed in prokaryotic genomes. Nucleic Acids Res. 2013 Jul;41(13):6514-30.
    Favorov A, Mularoni L, Cope LM, Medvedeva Y, Mironov AA, Makeev VJ, Wheelan SJ. (2012) Exploring massive, genome scale datasets with the GenometriCorr package. PLoS Comput Biol. May;8(5):e1002529
  17. Medvedeva YA, Fridman MV, Oparina NJ, Malko DB, Ermakova EO, Kulakovskiy IV, Heinzel A, Makeev VJ. (2010) Intergenic, gene terminal, and intragenic CpG islands in the human genome. BMC Genomics. Jan 19;11:48.
  18. Antonov I, Borodovsky M. Genetack: frameshift identification in protein-coding sequences by the Viterbi algorithm. J Bioinform Comput Biol. 2010 Jun; 8(3):535-51.