Egor B. Prokhorchuk Corresponding Member of the Russian Academy of Sciences Professor, Dr.Sci. (Biology) Head of Laboratory INB, room 203, 212  +7 (499) 135-53-37 prokhortchouk@biengi.ac.ru

Research directions

• Study of epigenetic information realization in the case of DNA damage
• Editing the genome of mammalian cells using the CRISPR / Cas9 system
• Investigation of increased NaCl concentration effect on the process of somatic reprogramming
• Study of epigenetic changes in the process of reprogramming mouse embryonic fibroblasts deprived protein CaI
• Investigation of resistance to inflammatory processes and the formation of Kaiso- and mice tumors
• Study of the role of ubiquitin ligase VHL and hypoxia-induced HIF1a in normal and pathology of human kidney cells
• Evaluation of the epigenetic response of the genome to changes in the level of HIF1a in normal and pathological conditions
• Influence of epigenetic mechanisms on the immune response
• Bioinformatics and Computational Biology
• Paleogeneomics

Key achievements

• Characterization of methyl-DNA-binding protein Kaiso
• In collaboration with Edinburgh University Laboratory received a line of mice with the genetic knockout of the Kaiso (KO) gene
• Application of minimally invasive method for modelling myocardial infarction in mice with the aid of ligation of the coronary artery of the heart
• Full-genomic association study was conducted to find single nucleotide polymorphisms associated with the onset of kidney cancer
• Study of osmotic stress effect of on epigenetic mechanisms in the process of reprogramming mammalian cells
• Bioinformatics