Laboratory of Vertebrate Genomics and Epigenomics

прохорчук Egor B. Prokhorchuk
Professor, Dr.Sci. (Biology)
Head of Laboratory
INB, room 203, 212
Телефон +7 (499) 135-53-37
E-Mail prokhortchouk@biengi.ac.ru

Research directions

  • Study of epigenetic information realization in the case of DNA damage
  • Editing the genome of mammalian cells using the CRISPR / Cas9 system
  • Investigation of increased NaCl concentration effect on the process of somatic reprogramming
  • Study of epigenetic changes in the process of reprogramming mouse embryonic fibroblasts deprived protein CaI
  • Investigation of resistance to inflammatory processes and the formation of Kaiso- and mice tumors
  • Study of the role of ubiquitin ligase VHL and hypoxia-induced HIF1a in normal and pathology of human kidney cells
  • Evaluation of the epigenetic response of the genome to changes in the level of HIF1a in normal and pathological conditions
  • Influence of epigenetic mechanisms on the immune response
  • Bioinformatics and Computational Biology
  • Paleogeneomics

Key achievements

  • Characterization of methyl-DNA-binding protein Kaiso
  • In collaboration with Edinburgh University Laboratory received a line of mice with the genetic knockout of the Kaiso (KO) gene
  • Application of minimally invasive method for modelling myocardial infarction in mice with the aid of ligation of the coronary artery of the heart
  • Full-genomic association study was conducted to find single nucleotide polymorphisms associated with the onset of kidney cancer
  • Study of osmotic stress effect of on epigenetic mechanisms in the process of reprogramming mammalian cells
  • Bioinformatics